Cognition following chimeric antigen receptor T-cell therapy: A systematic review
Journal Title
Journal of Autoimmunity
Publication Type
Review
Abstract
BACKGROUND: This systematic review aimed to characterise the cognitive outcomes of patients who received chimeric antigen receptor T-cell therapy. METHODS: A systematic search of the literature was performed using PubMed, PsycINFO, SCOPUS, EMBASE, Medline, and CINAHL (February 2023). Risk of bias was assessed using the JBI Checklist for Case Reports and the Risk of Bias Assessment Tool for Non-randomised Studies. RESULTS: Twenty-two studies met inclusion criteria with a total of 1104 participants. There was considerable methodological heterogeneity with differing study designs (e.g., cohort studies, clinical trials, case studies, a qualitative interview, and a focus group), measures of cognition (e.g., self-report, neuropsychological measures, clinician assessed/neurological examinations), and longest follow-up time points (i.e., five days to five years). DISCUSSION: Results of the studies were heterogenous with studies demonstrating stable, improved, or reduced cognition across differing time points. Overall, cognitive symptoms are common particularly in the acute stage (<2 weeks) post-infusion. Most deficits that arise in the acute stage resolve within one to two weeks, however, there is a subset of patients who continue to experience and self-report persistent deficits in the subacute and chronic stages. Future studies are needed to comprehensively analyse cognition using a combination of self-report and psychometric measures following chimeric antigen receptor T-cell therapy in the acute, subacute, and chronic settings.
Publisher
Elsevier
Keywords
Chimeric antigen receptor T-cell therapy; Cognition; Haematological cancer; Neurotoxicity
Department(s)
Clinical Haematology
PubMed ID
37837807
Open Access at Publisher's Site
https://doi.org/10.1016/j.jaut.2023.103126
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-12-05 12:35:27
Last Modified: 2023-12-05 12:50:03

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