Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and gammadelta T cell perturbations

Habel, JR; Chua, BY; Kedzierski, L; Selva, KJ; Damelang, T; Haycroft, ER; Nguyen, TH; Koay, HF; Nicholson, S; McQuilten, HA; Jia, X; Allen, LF; Hensen, L; Zhang, W; van de Sandt, CE; Neil, JA; Pragastis, K; Lau, JS; Jumarang, J; Allen, EK; Amanant, F; Krammer, F; Wragg, KM; Juno, JA; Wheatley, AK; Tan, HX; Pell, G; Walker, S; Audsley, J; Reynaldi, A; Thevarajan, I; Denholm, JT; Subbarao, K; Davenport, MP; Hogarth, PM; Godfrey, DI; Cheng, AC; Tong, SY; Bond, K; Williamson, DA; McMahon, JH; Thomas, PG; Pannaraj, PS; James, F; Holmes, NE; Smibert, OC; Trubiano, JA; Gordon, CL; Chung, AW; Whitehead, CL; Kent, SJ; Lappas, M; Rowntree, LC; Kedzierska, K

Author(s): Habel, JR; Chua, BY; Kedzierski, L; Selva, KJ; Damelang, T; Haycroft, ER; Nguyen, TH; Koay, HF; Nicholson, S; McQuilten, HA; Jia, X; Allen, LF; Hensen, L; Zhang, W; van de Sandt, CE; Neil, JA; Pragastis, K; Lau, JS; Jumarang, J; Allen, EK; Amanant, F; Krammer, F; Wragg, KM; Juno, JA; Wheatley, AK; Tan, HX; Pell, G; Walker, S; Audsley, J; Reynaldi, A; Thevarajan, I; Denholm, JT; Subbarao, K; Davenport, MP; Hogarth, PM; Godfrey, DI; Cheng, AC; Tong, SY; Bond, K; Williamson, DA; McMahon, JH; Thomas, PG; Pannaraj, PS; James, F; Holmes, NE; Smibert, OC; Trubiano, JA; Gordon, CL; Chung, AW; Whitehead, CL; Kent, SJ; Lappas, M; Rowntree, LC; Kedzierska, K;
Details: Publication Year 2023,Volume 8,Issue #6,Page e167157
Journal Title: JCI Insight
Publication Type: Research article
Abstract: Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in unvaccinated pregnant and nonpregnant women with acute and convalescent COVID-19, quantifying 217 immunological parameters. Humoral responses to SARS-CoV-2 were similar in pregnant and nonpregnant women, although our systems serology approach revealed distinct antibody and FcgammaR profiles between pregnant and nonpregnant women. Cellular analyses demonstrated marked differences in NK cell and unconventional T cell activation dynamics in pregnant women. Healthy pregnant women displayed preactivated NK cells and gammadelta T cells when compared with healthy nonpregnant women, which remained unchanged during acute and convalescent COVID-19. Conversely, nonpregnant women had prototypical activation of NK and gammadelta T cells. Activation of CD4+ and CD8+ T cells and T follicular helper cells was similar in SARS-CoV-2-infected pregnant and nonpregnant women, while antibody-secreting B cells were increased in pregnant women during acute COVID-19. Elevated levels of IL-8, IL-10, and IL-18 were found in pregnant women in their healthy state, and these cytokine levels remained elevated during acute and convalescent COVID-19. Collectively, we demonstrate perturbations in NK cell and gammadelta T cell activation in unvaccinated pregnant women with COVID-19, which may impact disease progression and severity during pregnancy.
Publisher: American Society for Clinical Investigation
Keywords: Pregnancy; Female; Humans; *covid-19; SARS-CoV-2; Killer Cells, Natural; CD8-Positive T-Lymphocytes; Antibodies
Department(s): Infectious Diseases
PubMed ID: 37036008
Publisher's Version: https://doi.org/10.1172/jci.insight.167157
Open Access at Publisher's Site: 10.1172/jci.insight.167157
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-11-30 06:12:33

Last Modified: 2024-07-10 08:37:52