Stem-like exhausted and memory CD8+ T cells in cancer
- Author(s)
- Gebhardt, T; Park, SL; Parish, IA;
- Journal Title
- Nature Reviews Cancer
- Publication Type
- Review
- Abstract
- T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The latter encompass stem-like exhausted T cells and memory T cells, both of which have recently emerged as key determinants of cancer immunity and response to immunotherapy. Here, we discuss key similarities and differences in the regulation and function of stem-like exhausted CD8(+) T cells and memory CD8(+) T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer, including tumour escape, long-term control and eradication. Finally, we emphasize how recent advances in the understanding of the molecular regulation of stem-like exhausted T cells and memory T cells are being explored for clinical benefit in cancer immunotherapies such as checkpoint inhibition, adoptive cell therapy and vaccination.
- Publisher
- Springer Nature
- Keywords
- Humans; *CD8-Positive T-Lymphocytes; Memory T Cells; *Neoplasms/therapy; Cell Differentiation; Stem Cells
- Department(s)
- Laboratory Research
- PubMed ID
- 37821656
- Publisher's Version
- https://doi.org/10.1038/s41568-023-00615-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-11-30 06:12:30
Last Modified: 2023-11-30 06:21:19