Stem-like exhausted and memory CD8+ T cells in cancer
Journal Title
Nature Reviews Cancer
Publication Type
Review
Abstract
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The latter encompass stem-like exhausted T cells and memory T cells, both of which have recently emerged as key determinants of cancer immunity and response to immunotherapy. Here, we discuss key similarities and differences in the regulation and function of stem-like exhausted CD8(+) T cells and memory CD8(+) T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer, including tumour escape, long-term control and eradication. Finally, we emphasize how recent advances in the understanding of the molecular regulation of stem-like exhausted T cells and memory T cells are being explored for clinical benefit in cancer immunotherapies such as checkpoint inhibition, adoptive cell therapy and vaccination.
Publisher
Springer Nature
Keywords
Humans; *CD8-Positive T-Lymphocytes; Memory T Cells; *Neoplasms/therapy; Cell Differentiation; Stem Cells
Department(s)
Laboratory Research
PubMed ID
37821656
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-11-30 06:12:30
Last Modified: 2023-11-30 06:21:19
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