Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the Literature
Author(s)
John, A; Spain, L; Hamid, AA;
Journal Title
Current Oncology
Publication Type
Review
Abstract
Non-clear cell renal cell carcinoma (nccRCC) is an entity comprised of a heterogeneous constellation of RCC subtypes. Genomic profiling has broadened our understanding of molecular pathogenic mechanisms unique to individual nccRCC subtypes. To date, clinical trials evaluating the use of immunotherapies and targeted therapies have predominantly been conducted in patients with clear cell histology. A comprehensive review of the literature has been undertaken in order to describe molecular pathogenic mechanisms pertaining to each nccRCC subtype, and concisely summarise findings from therapeutic trials conducted in the nccRCC space.
Publisher
MDPI
Keywords
Humans; *Carcinoma, Renal Cell/therapy/drug therapy; *Kidney Neoplasms/therapy/drug therapy; Molecular Targeted Therapy; Immunotherapy
Department(s)
Medical Oncology
PubMed ID
36661719
Open Access at Publisher's Site
https://doi.org/10.3390/curroncol30010070
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-05-30 07:27:51
Last Modified: 2023-05-30 07:28:52

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