Navigating the Current Landscape of Non-Clear Cell Renal Cell Carcinoma: A Review of the Literature
- Journal Title
- Current Oncology
- Publication Type
- Review
- Abstract
- Non-clear cell renal cell carcinoma (nccRCC) is an entity comprised of a heterogeneous constellation of RCC subtypes. Genomic profiling has broadened our understanding of molecular pathogenic mechanisms unique to individual nccRCC subtypes. To date, clinical trials evaluating the use of immunotherapies and targeted therapies have predominantly been conducted in patients with clear cell histology. A comprehensive review of the literature has been undertaken in order to describe molecular pathogenic mechanisms pertaining to each nccRCC subtype, and concisely summarise findings from therapeutic trials conducted in the nccRCC space.
- Publisher
- MDPI
- Keywords
- Humans; *Carcinoma, Renal Cell/therapy/drug therapy; *Kidney Neoplasms/therapy/drug therapy; Molecular Targeted Therapy; Immunotherapy
- Department(s)
- Medical Oncology
- PubMed ID
- 36661719
- Publisher's Version
- https://doi.org/10.3390/curroncol30010070
- Open Access at Publisher's Site
https://doi.org/10.3390/curroncol30010070- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-05-30 07:27:51
Last Modified: 2023-05-30 07:28:52