Modifiable lifestyle risk factors and survival after diagnosis with multiple myeloma
- Author(s)
- Cheah, S; Bassett, JK; Bruinsma, FJ; Hopper, J; Jayasekara, H; Joshua, D; MacInnis, RJ; Prince, HM; Southey, MC; Vajdic, CM; van Leeuwen, MT; Wong Doo, N; Harrison, SJ; English, DR; Giles, GG; Milne, RL;
- Details
- Publication Year 2023-09-08,Volume 16,Issue #10,Page 773-783
- Journal Title
- Expert Review of Hematology
- Publication Type
- Research article
- Abstract
- BACKGROUND: While remaining incurable, median overall survival for MM now exceeds 5 years. Yet few studies have investigated how modifiable lifestyle factors influence survival. We investigate whether adiposity, diet, alcohol, or smoking are associated with MM-related fatality. RESEARCH DESIGN AND METHODS: We recruited 760 incident cases of MM via cancer registries in two Australian states during 2010-2016. Participants returned questionnaires on health and lifestyle. Follow-up ended in 2020. Flexible parametric survival models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for lifestyle exposures and risk of all-cause and MM-specific fatality. RESULTS: Higher pre-diagnosis Alternative Healthy Eating Index (AHEI) scores were associated with reduced MM-specific fatality (per 10-unit score, HR = 0.84, 95%CI = 0.70-0.99). Pre-diagnosis alcohol consumption was inversely associated with MM-specific fatality, compared with nondrinkers (0.1-20 g per day, HR = 0.59, 95%CI = 0.39-0.90; >20 g per day, HR = 0.67, 95%CI = 0.40-1.13). Tobacco smoking was associated with increased all-cause fatality compared with never smoking (former smokers: HR = 1.44, 95%CI = 1.10-1.88; current smokers: HR = 1.30, 95%CI = 0.80-2.10). There was no association between pre-enrollment body mass index (BMI) and MM-specific or all-cause fatality. CONCLUSIONS: Our findings support established recommendations for healthy diets and against smoking. Higher quality diet, as measured by the AHEI, may improve survival post diagnosis with MM.
- Publisher
- Taylor & Francis
- Keywords
- Multiple myeloma; adiposity; alcohol; diet; fatality; survival; tobacco
- Department(s)
- Clinical Haematology
- PubMed ID
- 37667498
- Publisher's Version
- https://doi.org/10.1080/17474086.2023.2255747
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-11-14 03:57:57
Last Modified: 2024-07-09 05:13:35