Chronic lymphocytic leukaemia Australasian consensus practice statement
Details
Publication Year 2023-09,Volume 53,Issue #9,Page 1678-1691
Journal Title
Internal Medicine Journal
Publication Type
Guideline
Abstract
Chronic lymphocytic leukaemia (CLL) is the most common haematological malignancy in Australia and New Zealand (ANZ). Considerable changes to diagnostic and management algorithms have occurred within the last decade. The availability of next-generation sequencing and measurable residual disease assessment by flow cytometry allow for advanced prognostication and response assessments. Novel therapies, including inhibitors of Bruton's tyrosine kinase (BTKi) and B-cell lymphoma 2 (BCL2) inhibitors, have transformed the treatment landscape for both treatment-naive and relapsed/refractory disease, particularly for patients with high-risk genetic aberrations. Recommendations regarding appropriate supportive management continue to evolve, and special considerations are required for patients with CLL with respect to the global SARS-CoV-2 pandemic. The unique funding and treatment environments in Australasia highlight the need for specific local guidance with respect to the investigation and management of CLL. This consensus practice statement was developed by a broadly representative group of ANZ experts in CLL with endorsement by peak haematology bodies, with a view to providing this standardised guidance.
Publisher
Wiley
Keywords
Humans; *Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/genetics/therapy; Consensus; *covid-19; SARS-CoV-2; *Hematologic Neoplasms; Cll; diagnosis; management
Department(s)
Clinical Haematology
PubMed ID
37743239
Open Access at Publisher's Site
https://doi.org/10.1111/imj.16207
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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