Next-generation sequencing of baseline genetic mutations and outcomes of eltrombopag and azacitidine therapy in patients with myelodysplastic syndromes and thrombocytopenia: Data from the SUPPORT clinical trial
- Author(s)
- Ramos, PM; Choi, J; Campbell, CD; Wang, YA; Pallaud, C; Dickinson, M; Verma, A; Mittelman, M; Platzbecker, U; Cherif, H; Fenaux, P;
- Details
- Publication Year 2023-08,Volume 4,Issue #3,Page 876-881
- Journal Title
- eJHaem
- Publication Type
- Research article
- Abstract
- Eltrombopag has been previously shown to be effective in reversing azacitidine-mediated thrombocytopenia. This was further investigated in the SUPPORT trial, a phase III study assessing the efficacy/safety of eltrombopag plus azacitidine in patients with intermediate- to high-risk myelodysplastic syndromes and thrombocytopenia. The results did not support a clinical benefit for the addition of eltrombopag to azacitidine. We investigated if the somatic mutational profiles in the patient cohort were associated with treatment outcomes. Based on the available data, we observed no imbalance in the mutational profiles between treatment arms or a clear association between identified somatic mutations and clinical outcomes.
- Publisher
- Wiley
- Keywords
- Ngs; azacitidine; myelodysplastic syndromes; thrombocytopenia; thrombopoietin receptor agonist
- Department(s)
- Clinical Haematology
- PubMed ID
- 37601870
- Publisher's Version
- https://doi.org/10.1002/jha2.694
- Open Access at Publisher's Site
https://doi.org/10.1002/jha2.694- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-11-08 07:27:58
Last Modified: 2023-11-08 07:28:27