Vaccine schedule recommendations and updates for patients with hematologic malignancy post-hematopoietic cell transplant or CAR T-cell therapy
- Author(s)
- Reynolds, G; Hall, VG; Teh, BW;
- Details
- Publication Year 2023-07-29,Volume 25,Issue #Suppl 1,Page e14109
- Journal Title
- Transplant Infectious Disease
- Publication Type
- Online publication before print
- Abstract
- Revaccination after receipt of a hematopoietic cell transplant (HCT) or cellular therapies is a pillar of patient supportive care, with the potential to reduce morbidity and mortality linked to vaccine-preventable infections. This review synthesizes national, international, and expert consensus vaccination schedules post-HCT and presents evidence regarding the efficacy of newer vaccine formulations for pneumococcus, recombinant zoster vaccine, and coronavirus disease 2019 in patients with hematological malignancy. Revaccination post-cellular therapies are less well defined. This review highlights important considerations around poor vaccine response, seroprevalence preservation after cellular therapies, and the optimal timing of revaccination. Future research should assess the immunogenicity and real-world effectiveness of new vaccine formulations and/or vaccine schedules in patients post-HCT and cellular therapy, including analysis of vaccine response that relates to the target of cellular therapies.
- Publisher
- Wiley
- Keywords
- CAR-T cell; bispecific; cellular therapy; hematologic malignancy; stem cell transplant; vaccination
- Department(s)
- Infectious Diseases
- PubMed ID
- 37515788
- Publisher's Version
- https://doi.org/10.1111/tid.14109
- Open Access at Publisher's Site
https://doi.org/10.1111/tid.14109- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-10-24 12:19:58
Last Modified: 2024-09-05 06:55:57