An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
Details
Publication Year 2023-07-20,Volume 13,Issue #1,Page 11702
Journal Title
Scientific Reports
Publication Type
Research article
Abstract
Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated upon UVR-induced DNA damage, is linked to expression of interleukin-12 (IL-12) which serves to limit immunosuppression and augment the DNA repair process. Herein, we report an immunomodulating peptide, designated IK14800, that not only elicits secretion of IL-12, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) but also reduces DNA damage in the skin following exposure to UVR. Combined with re-invigoration of exhausted CD4+ T cells, inhibition of UVR-induced MMP-1 release and suppression of B16F10 melanoma metastases, IK14800 offers an opportunity to gain further insight into mechanisms underlying the development and progression of skin cancers.
Publisher
Springer Nature
Keywords
Humans; Ultraviolet Rays/adverse effects; Immunosuppression Therapy/adverse effects; DNA Damage; DNA Repair; *Melanoma/etiology; Interleukin-12; *Skin Neoplasms/complications
Department(s)
Laboratory Research
PubMed ID
37474630
Open Access at Publisher's Site
https://doi.org/10.1038/s41598-023-38890-4
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-10-17 06:55:44
Last Modified: 2023-10-17 06:58:32

© 2024 The Walter and Eliza Hall Institute of Medical Research. Access to this website is subject to our Privacy Policy and Terms of Use

An error has occurred. This application may no longer respond until reloaded. Reload 🗙