An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
- Author(s)
- Agrez, M; Rybchyn, MS; De Silva, WGM; Mason, RS; Chandler, C; Piva, TJ; Thurecht, K; Fletcher, N; Liu, F; Subramaniam, G; Howard, CB; Blyth, B; Parker, S; Turner, D; Rzepecka, J; Knox, G; Nika, A; Hall, A; Gooding, H; Gallagher, L;
- Details
- Publication Year 2023-07-20,Volume 13,Issue #1,Page 11702
- Journal Title
- Scientific Reports
- Publication Type
- Research article
- Abstract
- Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated upon UVR-induced DNA damage, is linked to expression of interleukin-12 (IL-12) which serves to limit immunosuppression and augment the DNA repair process. Herein, we report an immunomodulating peptide, designated IK14800, that not only elicits secretion of IL-12, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) but also reduces DNA damage in the skin following exposure to UVR. Combined with re-invigoration of exhausted CD4+ T cells, inhibition of UVR-induced MMP-1 release and suppression of B16F10 melanoma metastases, IK14800 offers an opportunity to gain further insight into mechanisms underlying the development and progression of skin cancers.
- Publisher
- Springer Nature
- Keywords
- Humans; Ultraviolet Rays/adverse effects; Immunosuppression Therapy/adverse effects; DNA Damage; DNA Repair; *Melanoma/etiology; Interleukin-12; *Skin Neoplasms/complications
- Department(s)
- Laboratory Research
- PubMed ID
- 37474630
- Publisher's Version
- https://doi.org/10.1038/s41598-023-38890-4
- Open Access at Publisher's Site
https://doi.org/10.1038/s41598-023-38890-4- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-10-17 06:55:44
Last Modified: 2023-10-17 06:58:32