The Challenge of Diagnosing Invasive Pulmonary Aspergillosis in Children: A Review of Existing and Emerging Tools
- Author(s)
- Yeoh, DK; McMullan, BJ; Clark, JE; Slavin, MA; Haeusler, GM; Blyth, CC;
- Details
- Publication Year 2023-04-08,Volume 188,Issue #5,Page 731-743
- Journal Title
- Mycopathologia
- Publication Type
- Review
- Abstract
- Invasive pulmonary aspergillosis remains a major cause of morbidity and mortality for immunocompromised children, particularly for patients with acute leukaemia and those undergoing haematopoietic stem cell transplantation. Timely diagnosis, using a combination of computed tomography (CT) imaging and microbiological testing, is key to improve prognosis, yet there are inherent challenges in this process. For CT imaging, changes in children are generally less specific than those reported in adults and recent data are limited. Respiratory sampling by either bronchoalveolar lavage or lung biopsy is recommended but is not always feasible in children, and serum biomarkers, including galactomannan, have important limitations. In this review we summarise the current paediatric data on available diagnostic tests for IPA and highlight key emerging diagnostic modalities with potential for future use.
- Publisher
- Springer Nature
- Keywords
- Aspergillus; Children; Diagnostic imaging; Diagnostic mycology; Invasive pulmonary aspergillosis
- Department(s)
- Infectious Diseases
- PubMed ID
- 37040020
- Publisher's Version
- https://doi.org/10.1007/s11046-023-00714-4
- Open Access at Publisher's Site
https://doi.org/10.1007/s11046-023-00714-4- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-10-17 05:18:56
Last Modified: 2023-10-17 05:19:13