The Challenge of Diagnosing Invasive Pulmonary Aspergillosis in Children: A Review of Existing and Emerging Tools
Details
Publication Year 2023-04-08,Volume 188,Issue #5,Page 731-743
Journal Title
Mycopathologia
Publication Type
Review
Abstract
Invasive pulmonary aspergillosis remains a major cause of morbidity and mortality for immunocompromised children, particularly for patients with acute leukaemia and those undergoing haematopoietic stem cell transplantation. Timely diagnosis, using a combination of computed tomography (CT) imaging and microbiological testing, is key to improve prognosis, yet there are inherent challenges in this process. For CT imaging, changes in children are generally less specific than those reported in adults and recent data are limited. Respiratory sampling by either bronchoalveolar lavage or lung biopsy is recommended but is not always feasible in children, and serum biomarkers, including galactomannan, have important limitations. In this review we summarise the current paediatric data on available diagnostic tests for IPA and highlight key emerging diagnostic modalities with potential for future use.
Publisher
Springer Nature
Keywords
Aspergillus; Children; Diagnostic imaging; Diagnostic mycology; Invasive pulmonary aspergillosis
Department(s)
Infectious Diseases
PubMed ID
37040020
Open Access at Publisher's Site
https://doi.org/10.1007/s11046-023-00714-4
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-10-17 05:18:56
Last Modified: 2023-10-17 05:19:13

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