Role of Ovarian Suppression in Early Premenopausal Breast Cancer
- Author(s)
- Francis, PA;
- Details
- Publication Year 2023-02,Volume 37,Issue #1,Page 79-88
- Journal Title
- Hematology/Oncology Clinics of North America
- Publication Type
- Review
- Abstract
- The benefit from removing ovaries to control premenopausal breast cancer growth was identified more than 100 years ago. Subsequent identification of estrogen receptor (ER) enabled targeting of this approach. Development of gonadotropin-releasing hormone agonists facilitated a reversible method of ovarian function suppression, suitable for young women with early breast cancer. Clinical trials have established the value of including ovarian suppression to reduce recurrence of ER-positive premenopausal early breast cancer. Ovarian suppression administered with chemotherapy can reduce the risk of premature menopause in ER-negative cancer, and increase the prospect of future pregnancy in premenopausal women, regardless of tumor hormone receptor status.
- Publisher
- Elsevier
- Keywords
- Female; Humans; *Ovary/pathology; *Breast Neoplasms/drug therapy/pathology; Premenopause; Adjuvant endocrine therapy; Early breast cancer; Estrogen receptor-positive; Ovarian suppression
- Department(s)
- Medical Oncology
- PubMed ID
- 36435615
- Publisher's Version
- https://doi.org/10.1016/j.hoc.2022.08.006
- Open Access at Publisher's Site
10.1016/j.hoc.2022.08.006- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-04-06 06:53:47
Last Modified: 2024-07-10 06:36:39