Tumour-infiltrating lymphocytes and breast radiotherapy: perspectives from the International Immuno-Oncology Biomarker Working Group

Gunster, JLB; Tramm, T; Machiels, M; Demaria, S; Formenti, SC; De Caluwe, A; Duane, F; Klein, J; Sur, D; Somaiah, N; Rakovitch, E; Jerzak, KJ; Lu, FI; Hiley, CT; Brackstone, M; Ehinger, A; Maley, SK; Acs, B; Zerdes, I; Ozcan, D; Khramtsov, A; Salido, E; Papathomas, TG; Sharma, P; Stecklein, S; Khramtsova, G; Horvath, Z; Markov, D; Hardas, A; Do Prado Moura, JF; Ramirez, A; Woodward, WA; Sivapiragasam, A; Denkert, C; Michiels, S; Loi, S; Poortmans, P; Mutter, RW; Salgado, R; Tran, WT; International Immuno-Oncology Biomarker Working Group

Author(s): Gunster, JLB; Tramm, T; Machiels, M; Demaria, S; Formenti, SC; De Caluwe, A; Duane, F; Klein, J; Sur, D; Somaiah, N; Rakovitch, E; Jerzak, KJ; Lu, FI; Hiley, CT; Brackstone, M; Ehinger, A; Maley, SK; Acs, B; Zerdes, I; Ozcan, D; Khramtsov, A; Salido, E; Papathomas, TG; Sharma, P; Stecklein, S; Khramtsova, G; Horvath, Z; Markov, D; Hardas, A; Do Prado Moura, JF; Ramirez, A; Woodward, WA; Sivapiragasam, A; Denkert, C; Michiels, S; Loi, S; Poortmans, P; Mutter, RW; Salgado, R; Tran, WT; International Immuno-Oncology Biomarker Working Group;
Details: Publication Year 2026-09,Volume 27,Issue #9,Page e420-e433
Journal Title: Lancet Oncology
Publication Type: Review
Abstract: Tumour-infiltrating lymphocytes (TILs) are prognostic and predictive biomarkers in breast cancer. High pre-treatment TILs are associated with a favourable prognosis and improved response to systemic therapies. However, the role of TILs in mediating response to radiotherapy in breast cancer remains underexplored, with scarce clinical evidence to date. In this Review, we present an overview of current evidence and potential mechanisms, highlight opportunities for integrating TILs into radiation oncology trials and clinical practice, and call for standardised TIL reporting to accelerate biomarker-driven individualisation of radiotherapy in breast cancer.
Publisher: Elsevier
Keywords: Humans; *Lymphocytes, Tumor-Infiltrating/immunology/radiation effects; *Breast Neoplasms/radiotherapy/immunology/pathology; Female; *Biomarkers, Tumor/immunology; Prognosis
Department(s): Laboratory Research; Medical Oncology
Publisher's Version: https://doi.org/10.1016/s1470-2045(26)00255-x
Open Access at Publisher's Site: https://doi.org/10.1016/s1470-2045(26)00255-x
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-11-12 06:04:09

Last Modified: 2026-11-12 06:04:17