Cost-effectiveness analysis of home-based rehabilitation compared to usual care for people with inoperable lung cancer

Edbrooke, L; Denehy, L; Patrick, C; Tuffaha, H

Author(s): Edbrooke, L; Denehy, L; Patrick, C; Tuffaha, H;
Details: Publication Year 2021-11,Volume 30,Issue #6,Page e13501
Journal Title: European Journal of Cancer Care
Publication Type: Research article
Abstract: OBJECTIVE: Few economic evaluations of lung cancer rehabilitation exist. The aim of this study was to assess the cost-effectiveness of providing home-based rehabilitation for inoperable lung cancer. METHODS: A cost-utility analysis alongside a randomised controlled trial (RCT) of rehabilitation compared with usual care. The primary outcome was quality-adjusted life years (QALYs) gained. The incremental cost-effectiveness ratio [ICER (95% CI)] and the net monetary benefit are reported. Value of information (VOI) analysis assessed the need/value of more research. RESULTS: Seventy participants (34 intervention and 36 usual care), average (SD) age 63.0 (12.0) years, 32 (45.7%) stage IV. The average intervention cost was AU$3421 (AU$5352 usual care), and effect (QALY) was 0.30 (0.31 usual care). The ICER was AU$228,197 (-1,173,194 to 1,101,450) per QALY gained. The net monetary benefit was AU$1508, favouring the intervention. The probability that the intervention was more cost-effective than usual care, at a willingness to pay threshold of AU$50,000, was 75%. VOI analysis showed that additional research to resolve decision uncertainty is potentially worthwhile. CONCLUSION: A high degree of uncertainty exists regarding the cost-effectiveness of lung cancer rehabilitation. Further RCTs, powered for economic evaluations and utilising rehabilitation sensitive outcomes, are required to support translation of evidence into clinical practice.
Keywords: Cost-Benefit Analysis; Humans; *Lung Neoplasms; Middle Aged; Quality-Adjusted Life Years; Treatment Outcome; cost-effectiveness; exercise; lung cancer; rehabilitation; symptom management
Department(s): Allied Health
PubMed ID: 34396615
Publisher's Version: https://doi.org/10.1111/ecc.13501
Terms of Use/Rights Notice: Refer to copyright notice on published article.

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