From complexity to clarity: Building dashboards for hit selection in high throughput screens
- Author(s)
- Cowley, KJ; Allen, H; Simpson, KJ;
- Journal Title
- SLAS Discovery
- Publication Type
- Research article
- Abstract
- High throughput screening produces large, complex datasets that are difficult to interrogate without programming expertise, making hit selection time-consuming and inflexible. While instrument software and commercial tools offer partial solutions, they often lack adaptability or require costly infrastructure. Interactive dashboards provide an effective alternative by enabling dynamic filtering and integrated visualization within a single interface. Here, we present simple R Markdown-based templates for creating customizable, modular dashboards for screen data analysis. Built using the flexdashboard and crosstalk R packages, and HTML widgets, these lightweight, easy-to-build HTML dashboards require no complex installation process or installation of licensed software. They support linked visualizations, threshold-based filtering (e.g., Z-score, p-value, fold change), and interactive data exploration and are shared as a standalone HTML file. This framework enables rapid, flexible hit selection across diverse high throughput screening applications and is designed for users with basic R experience.
- Publisher
- Elsevier
- Keywords
- Dashboard; High content imaging; High throughput screening; Organoids; Synergy screening
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.slasd.2026.100324
- Open Access at Publisher's Site
https://doi.org/10.1016/j.slasd.2026.100324- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-08-11 02:01:22
Last Modified: 2026-09-03 12:44:10