Prognostic Value of Restaging [(18)F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [(177)Lu]Lu-PSMA-617 Therapy
- Author(s)
- Kashyap, R; Buteau, JP; Papa, N; Ayati, N; Eifer, M; Betech-Antar, V; Akhurst, T; Alipour, R; Kong, G; Saghebi, J; Ravi Kumar, AS; Cardin, A; Sandhu, S; Tran, B; Azad, AA; Murphy, DG; Hofman, MS;
- Journal Title
- Journal of Nuclear Medicine
- Publication Type
- Online publication before print
- Abstract
- We analyzed the prognostic value of an interim [(18)F]FDG PET/CT performed after cycle 3 of [(177)Lu]Lu-PSMA-617 ([(177)Lu]Lu-PSMA) for patients undergoing therapy for metastatic castration-resistant prostate cancer (mCRPC). Methods: We retrospectively reviewed the data of patients with mCRPC in the ProsTIC Registry (NCT04769817) receiving [(177)Lu]Lu-PSMA who underwent [(18)F]FDG PET/CT at both baseline and after cycle 3. Parameters included visual response assessment (progression vs. no progression) and metabolic tumor volume (MTV) (≥20% increase vs. <20% increase or any decrease). Outcomes were measured against reductions of 50% or greater in prostate-specific antigen (PSA) levels (PSA-50) by Fisher exact test and time-to-event outcomes. PSA progression-free survival (PFS) and overall survival (OS) were defined relative to cycle 3, using Kaplan-Meier estimation. Results: Thirty-four patients (median age, 72 y; interquartile range, 66-77 y) were eligible for study inclusion. Their median PSA was 58 ng/mL (interquartile range, 17-176 ng/mL) before treatment. All patients had prior treatment with androgen receptor pathway inhibitors, and 33 had received at least 1 line of chemotherapy. Visual progression on interim [(18)F]FDG PET was observed in 18 patients (53%) and was associated with shorter median PFS after cycle 3 (1.2 mo; 95% CI, 0.7-2.0) compared with those patients without visual progression (5.2 mo; 95% CI, 3.6-7.0) (P = 0.0005) and lower achievement of PSA-50 (28% vs. 75%, P = 0.015). Median OS did not significantly differ between those with and without visual progression (10.3 mo; 95% CI, 6.1-17.1 mo vs. 16.4 mo; 95% CI, 10.5-21.4 mo, respectively) (P = 0.090). An increase of at least 20% in MTV was observed in 11 patients (32%) who, when compared with those whose MTV increased or decreased by less than 20%, had a shorter median PFS (0.7 mo; 95% CI, 0.6-1.4 mo vs. 4.9 mo; 95% CI, 2.2-6.6 mo; P < 0.0001) and OS (10.8 mo; 95% CI, 2.1-17.1 mo vs. 16.4 mo; 95% CI, 10.3-20.1 mo; P = 0.069) and lower PSA-50 response (9.1% vs. 70%, P = 0.002). Conclusion: Visual and quantified changes on interim [(18)F]FDG PET appeared prognostic for PFS in patients undergoing [(177)Lu]Lu-PSMA therapy and correlated with PSA response. Further studies are needed to determine whether [(18)F]FDG PET could serve as an independent biomarker to guide treatment intensification or de-escalation, including treatment pauses.
- Keywords
- Fdg pet; Lu-PSMA; Psma; prostate-specific membrane antigen; radiopharmaceutical therapy; theranostics
- Department(s)
- Cancer Imaging; Medical Oncology; Surgical Oncology
- Publisher's Version
- https://doi.org/10.2967/jnumed.126.272531
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-07-07 05:56:13
Last Modified: 2026-07-07 05:56:24