Primary Cutaneous Apocrine Carcinoma With Locoregional Disease: A Proposed Diagnostic and Therapeutic Framework

Author(s): Kumar, R; Devine, M; Angel, CM; Niumsawatt, V; Webb, A;
Details: Publication Year 2026-08-01,Volume 97,Issue #2,Page 218-221
Journal Title: Annals of Plastic Surgery
Publication Type: Case report
Abstract: Primary cutaneous apocrine carcinoma (PCAC) is a rare, low-grade cutaneous malignancy for which no standardized diagnostic or treatment algorithm currently exists. Clinical resemblance to other cutaneous malignancies and histopathologic overlap with other metastatic lesions often contribute to delays in diagnosis or misdiagnoses. Management is centered on wide-local-excision (WLE) and consideration of sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) as standard-of-care. We present a case of PCAC with locoregional metastasis. We propose a novel, systematic framework to guide clinicians in the diagnosis and management of this uncommon tumor. This addresses a critical gap in the existing literature.
Publisher: Wolters Kluwer
Keywords: Humans; *Sweat Gland Neoplasms/surgery/pathology/diagnosis; *Apocrine Glands/pathology/surgery; Sentinel Lymph Node Biopsy; Female; Lymph Node Excision; *Skin Neoplasms/surgery/pathology/diagnosis; Male; Non-Melanoma Skin Neoplasms; apocrine carcinoma; cutaneous malignancy; neoplasms
Department(s): Surgical Oncology; Pathology
Publisher's Version: https://doi.org/10.1097/sap.0000000000004761
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-05-28 04:25:05

Last Modified: 2026-08-04 04:43:07