Cytokine armored CAR T cells for cancer immunotherapy
- Details
- Publication Year 2026-05,Volume 104,Issue #5,Page 485-489
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Review
- Abstract
- Cytokine armoring of CAR T cells for enhancing the immunotherapy of cancer. Reprogramming of CAR T-cell phenotypes through (a) IL-15(8) or (b) IL-9Rα(9) engineering. Reprogramming of the tumor microenvironment and recruitment of host antitumor immunity through (c) IL-36γ(10) or (d) IL-12(11,12) engineering. (e) Tumor-inducible cytokine expression utilizing synthetic NFAT or endogenous NR4A2 promoter systems to restrict systemic expression of potent cytokines for improved safety.
- Publisher
- Wiley
- Keywords
- Humans; *Neoplasms/therapy/immunology; *Immunotherapy, Adoptive/methods; *Receptors, Chimeric Antigen/metabolism/genetics/immunology; *Cytokines/metabolism/genetics; Animals; Tumor Microenvironment/immunology; *T-Lymphocytes/immunology; Immunotherapy; CAR T cells; cytokine armoring; tumor microenvironment
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1111/imcb.70112
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-04-14 03:18:23
Last Modified: 2026-05-21 11:17:46