Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study

Mitri, EA; International Network of Antibiotic Allergy Nations (iNAAN) Study Group; Vogrin, S; Paynter, C; Fletcher, LR; Peter, J; Powell, N; Barnes, S; Li, PH; Copaescu, AM; Turner, NA; James, F; Sullivan, R; Masoum, MS; Rawlins, M; Mackay, G; Smith, BJ; Kilfoyle, P; Forster, D; Rose, M; Cowan, R; Alcorn, K; Brischetto, A; Mahony, A; Redmond, A; Chakravorty, A; Meher-Homji, Z; Yuson, C; Crawford, S; Weeks, G; Ponnampalavanar, SSS; Katelaris, C; Tran, P; O&#39;Hern, J; Godsell, J; Peel, TN; Sandaradura, I; New, D; Holland, C; Cutfield, T; Coghill, S; Hand, C; Williams, J; Bishop, J; Lambros, B; Day, C; Ierano, C; Holmes, NE; Roberts, JA; Fernando, SL; Klaic, M; Trubiano, JA

Author(s): Mitri, EA; International Network of Antibiotic Allergy Nations (iNAAN) Study Group; Vogrin, S; Paynter, C; Fletcher, LR; Peter, J; Powell, N; Barnes, S; Li, PH; Copaescu, AM; Turner, NA; James, F; Sullivan, R; Masoum, MS; Rawlins, M; Mackay, G; Smith, BJ; Kilfoyle, P; Forster, D; Rose, M; Cowan, R; Alcorn, K; Brischetto, A; Mahony, A; Redmond, A; Chakravorty, A; Meher-Homji, Z; Yuson, C; Crawford, S; Weeks, G; Ponnampalavanar, SSS; Katelaris, C; Tran, P; O'Hern, J; Godsell, J; Peel, TN; Sandaradura, I; New, D; Holland, C; Cutfield, T; Coghill, S; Hand, C; Williams, J; Bishop, J; Lambros, B; Day, C; Ierano, C; Holmes, NE; Roberts, JA; Fernando, SL; Klaic, M; Trubiano, JA;
Details: Publication Year 2026-06,Volume 82,Issue #6,Page e1163-e1170
Journal Title: Clinical Infectious Diseases
Publication Type: Research article
Abstract: In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.
Publisher: Oxford University Press
Keywords: Humans; *Penicillins/adverse effects/administration & dosage; *Drug Hypersensitivity/diagnosis; *Anti-Bacterial Agents/adverse effects/administration & dosage; Prospective Studies; Hospitals; Administration, Oral; Antimicrobial Stewardship; audit and feedback; implementation; oral challenge; penicillin allergy
Department(s): Infectious Diseases
Publisher's Version: https://doi.org/10.1093/cid/ciag083
Open Access at Publisher's Site: https://doi.org/10.1093/cid/ciag083
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-04-14 03:18:22

Last Modified: 2026-08-04 05:57:42