Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study
- Author(s)
- Mitri, EA; Vogrin, S; Paynter, C; Fletcher, LR; Peter, J; Powell, N; Barnes, S; Li, PH; Copaescu, AM; Turner, NA; James, F; Sullivan, R; Masoum, MS; Rawlins, M; Mackay, G; Smith, BJ; Kilfoyle, P; Forster, D; Rose, M; Cowan, R; Alcorn, K; Brischetto, A; Mahony, A; Redmond, A; Chakravorty, A; Meher-Homji, Z; Yuson, C; Crawford, S; Weeks, G; Ponnampalavanar, SSS; Katelaris, C; Tran, P; O'Hern, J; Godsell, J; Peel, TN; Sandaradura, I; New, D; Holland, C; Cutfield, T; Coghill, S; Hand, C; Williams, J; Bishop, J; Lambros, B; Day, C; Ierano, C; Holmes, NE; Roberts, JA; Fernando, SL; Klaic, M; Trubiano, JA; International Network of Antibiotic Allergy Nations (iNAAN) Study Group;
- Journal Title
- Clinical Infectious Diseases
- Publication Type
- Online publication before print
- Abstract
- In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.
- Keywords
- antimicrobial stewardship; audit and feedback; implementation; oral challenge; penicillin allergy
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1093/cid/ciag083
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-04-14 03:18:22
Last Modified: 2026-04-14 03:18:35