Marginal Zone Lymphoma: 2026 Update on Diagnosis and Management
- Author(s)
- Noor, WD; Seymour, JF; Cheah, CY;
- Details
- Publication Year 2026-06,Volume 101,Issue #6,Page 1320-1340
- Journal Title
- American Journal of Hematology
- Publication Type
- Review
- Abstract
- DISEASE OVERVIEW: Marginal zone lymphoma (MZL) is a heterogeneous group of indolent mature B-cell neoplasms with classically three major subtypes: nodal, splenic, and extranodal MZL of mucosa-associated lymphoid tissue (MALT). DIAGNOSIS: Diagnosis and disease evaluation of MZL is further advanced by the use of genomic testing and PET/CT with emerging evidence for the use of circulating tumor DNA. The RECLASS classification system proposed a hierarchical approach to classifying MZL while the FIL-NF10 investigators introduced a fourth MZL subtype, disseminated MZL. Though the prognosis of MZL varies between subtypes and stages, the MZL IPI and FLIPI24 indices can be used for prognostication. TREATMENT: Frontline treatment of MZL varies between localized disease and advanced-stage diseases. The former favor the use of local therapies such as radiotherapy and anti-microbial in certain subtypes with a selective role of rituximab monotherapy. The latter requires systemic immunotherapy ± chemotherapy with emerging data for cytotoxic-free and covalent Bruton tyrosine kinase inhibitor (cBTKi)-based regimens. cBTKi and immunomodulators are established in relapsed/refractory MZL, while data for antibody-drug conjugates, T-cell engagers, and potentially CAR T-cell therapies are maturing.
- Publisher
- Wiley
- Keywords
- Humans; *Lymphoma, B-Cell, Marginal Zone/therapy/diagnosis/classification; Disease Management; Prognosis; Rituximab/therapeutic use; Positron Emission Tomography Computed Tomography; Immunotherapy
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.1002/ajh.70289
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-04-07 12:09:48
Last Modified: 2026-05-19 06:10:13