Joint EANM/SNMMI procedure guideline for the use of 177Lu-labeled PSMA-targeted radioligand-therapy (177Lu-PSMA-RLT)

Kratochwil, C; Fendler, WP; Eiber, M; Hofman, MS; Emmett, L; Calais, J; Osborne, JR; Iravani, A; Koo, P; Lindenberg, L; Baum, RP; Bozkurt, MF; Delgado Bolton, RC; Ezziddin, S; Forrer, F; Hicks, RJ; Hope, TA; Kabasakal, L; Konijnenberg, M; Kopka, K; Lassmann, M; Mottaghy, FM; Oyen, WJG; Rahbar, K; Schoder, H; Virgolini, I; Bodei, L; Fanti, S; Haberkorn, U; Hermann, K

Author(s): Kratochwil, C; Fendler, WP; Eiber, M; Hofman, MS; Emmett, L; Calais, J; Osborne, JR; Iravani, A; Koo, P; Lindenberg, L; Baum, RP; Bozkurt, MF; Delgado Bolton, RC; Ezziddin, S; Forrer, F; Hicks, RJ; Hope, TA; Kabasakal, L; Konijnenberg, M; Kopka, K; Lassmann, M; Mottaghy, FM; Oyen, WJG; Rahbar, K; Schoder, H; Virgolini, I; Bodei, L; Fanti, S; Haberkorn, U; Hermann, K;
Details: Publication Year 2023-07,Volume 50,Issue #9,Page 2830-2845
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Publication Type: Guideline
Abstract: Prostate-specific membrane antigen (PSMA) is expressed by the majority of clinically significant prostate adenocarcinomas, and patients with target-positive disease can easily be identified by PSMA PET imaging. Promising results with PSMA-targeted radiopharmaceutical therapy have already been obtained in early-phase studies using various combinations of targeting molecules and radiolabels. Definitive evidence of the safety and efficacy of [(177)Lu]Lu-PSMA-617 in combination with standard-of-care has been demonstrated in patients with metastatic castration-resistant prostate cancer, whose disease had progressed after or during at least one taxane regimen and at least one novel androgen-axis drug. Preliminary data suggest that (177)Lu-PSMA-radioligand therapy (RLT) also has high potential in additional clinical situations. Hence, the radiopharmaceuticals [(177)Lu]Lu-PSMA-617 and [(177)Lu]Lu-PSMA-I&T are currently being evaluated in ongoing phase 3 trials. The purpose of this guideline is to assist nuclear medicine personnel, to select patients with highest potential to benefit from (177)Lu-PSMA-RLT, to perform the procedure in accordance with current best practice, and to prepare for possible side effects and their clinical management. We also provide expert advice, to identify those clinical situations which may justify the off-label use of [(177)Lu]Lu-PSMA-617 or other emerging ligands on an individual patient basis.
Publisher: Springer Nature
Keywords: Male; Humans; Prostate-Specific Antigen; *Prostatic Neoplasms, Castration-Resistant/diagnostic imaging/radiotherapy; Radiopharmaceuticals/adverse effects; *Nuclear Medicine; Heterocyclic Compounds, 1-Ring/therapeutic use; Dipeptides/therapeutic use; Lutetium/therapeutic use; Treatment Outcome; Eanm/snmmi; Psma; [177Lu]Lu-PSMA-617
Department(s): Cancer Imaging
PubMed ID: 37246997
Publisher's Version: https://doi.org/10.1007/s00259-023-06255-8
Open Access at Publisher's Site: https://doi.org/10.1007/s00259-023-06255-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-09-28 07:45:36

Last Modified: 2023-09-28 07:46:07