Health-related Quality of Life Outcomes of Salvage Metastasis-directed Treatment Versus Elective Nodal Treatment for Oligorecurrent Nodal Prostate Cancer: A Secondary Analysis of the Phase 2, Open-label PEACE V-STORM Randomized Trial
- Author(s)
- Zilli, T; Siva, S; Brabrand, S; Dirix, P; Liefhooghe, N; Otte, FX; Gomez-Iturriaga, A; Everaerts, W; Shelan, M; Conde-Moreno, A; Campos, FL; Papachristofilou, A; Guckenberger, M; Scorsetti, M; Zapatero, A; Iturre, AV; Eito, C; Couñago, F; Muto, P; Duthoy, W; Mach, N; Fonteyne, V; Moon, D; Thon, K; Mercier, C; Achard, V; Stellamans, K; Goetghebeur, E; Reynders, D; Ost, P;
- Journal Title
- European Urology Oncology
- Publication Type
- Online publication before print
- Abstract
- For prostate cancer patients with metachronous nodal oligorecurrences detected by positron emission tomography, the randomized phase 2 PEACE V-STORM trial (NCT03569241) demonstrated that, compared with metastasis-directed therapy (MDT), elective nodal pelvic radiotherapy (ENRT) in combination with 6 mo of androgen deprivation therapy (ADT) improved locoregional disease control and metastasis-free survival. In the 190 evaluable patients (MDT: 97 and ENRT: 93) of the 196 randomized in the study, health-related quality of life (HRQoL) was assessed by European Organization for Research and Treatment of Cancer QLQ-C-30 and QLQ-PR-25 questionnaires over a 4-yr period as a part of a statistically defined quality of life analysis. During a median follow-up of 50 mo (interquartile range 42-58), QLQ-C30 scores showed no significant differences between MDT and ENRT, except for worse physical functioning at month 24 in the ENRT group (mean decline -7.7 vs -1.3) and worse emotional functioning at month 12 in the MDT group (mean decline 5.8 vs -0.4, p = 0.034). No significant differences in QLQ-PR25 scores were observed, except slightly better bowel symptoms at 18 mo for ENRT, but with no difference before or after. The decline in sexual activity and increase in ADT-related symptoms during the first 6 mo were comparable between arms, returning to baseline by month 12. Consistent with physician-reported treatment-related adverse events, HRQoL analyses show no significant differences between ENRT and MDT.
- Department(s)
- Radiation Oncology; Surgical Oncology
- Publisher's Version
- https://doi.org/10.1016/j.euo.2026.01.001
- Open Access at Publisher's Site
https://doi.org/10.1016/j.euo.2026.01.001- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-02-03 03:57:06
Last Modified: 2026-02-03 03:57:13