Acute exercise induces distinct quantitative and phenotypical T cell profiles in men with prostate cancer
- Author(s)
- Hanson, ED; Sakkal, S; Bates-Fraser, LC; Que, S; Cho, E; Spielmann, G; Kadife, E; Violet, JA; Battaglini, CL; Stoner, L; Bartlett, DB; McConell, GK; Hayes, A;
- Journal Title
- Frontiers in Sports and Active Living
- Publication Type
- Research article
- Abstract
- BACKGROUND: Reduced testosterone levels can influence immune system function, particularly T cells. Exercise during cancer reduces treatment-related side effects and provide a stimulus to mobilize and redistribute immune cells. However, it is unclear how conventional and unconventional T cells (UTC) respond to acute exercise in prostate cancer survivors compared to healthy controls. METHODS: Age-matched prostate cancer survivors on androgen deprivation therapy (ADT) and those without ADT (PCa) along with non-cancer controls (CON) completed approximately 45 min of intermittent cycling with 3 min at 60% of peak power interspersed by 1.5 min of rest. Fresh, unstimulated immune cell populations and intracellular perforin were assessed before (baseline), immediately following (0 h), 2 h, and 24 h post-exercise. RESULTS: At 0 h, conventional T cell counts increased by 45%-64% with no differences between groups. T cell frequency decreased by -3.5% for CD3(+) and -4.5% for CD4(+) cells relative to base at 0 h with CD8(+) cells experiencing a delayed decrease of -4.5% at 2 h with no group differences. Compared to CON, the frequency of CD8(+)CD57(+) cells was -18.1% lower in ADT. Despite a potential decrease in maturity, ADT increased CD8(+)perforin(+) GMFI. CD3(+)Valpha7.2(+)CD161(+) counts, but not frequencies, increased by 69% post-exercise while CD3(+)CD56(+) cell counts increased by 127% and were preferentially mobilized (+1.7%) immediately following the acute cycling bout. There were no UTC group differences. Cell counts and frequencies returned to baseline by 24 h. CONCLUSION: Following acute exercise, prostate cancer survivors demonstrate normal T cell and UTC responses that were comparable to CON. Independent of exercise, ADT is associated with lower CD8(+) cell maturity (CD57) and perforin frequency that suggests a less mature phenotype. However, higher perforin GMFI may attenuate these changes, with the functional implications of this yet to be determined.
- Publisher
- Frontiers
- Keywords
- androgen deprivation therapy (ADT); conventional t cells (Tconv); exercise immunology; exercise induced immunosuppression; exercise oncology; unconventional t cells
- Department(s)
- Radiation Oncology; Cancer Imaging
- PubMed ID
- 37325799
- Publisher's Version
- https://doi.org/10.3389/fspor.2023.1173377
- Open Access at Publisher's Site
https://doi.org/10.3389/fspor.2023.1173377- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-09-19 07:39:53
Last Modified: 2023-09-19 07:40:43