Neural Gastric Electrical Stimulation: Future Prospects in Managing Gastric Emptying Disorders
- Author(s)
- Sivakumar, J; Furness, JB; Grayden, DB; Fallon, J; Cottrell, J; Duong, CP;
- Details
- Publication Year 2026-01-30,Volume 32,Issue #1,Page 19-29
- Journal Title
- Journal of Neurogastroenterology and Motility
- Publication Type
- Review
- Abstract
- Neural gastric electrical stimulation (NGES) is a multi-channel high-energy gastrointestinal stimulation technique that directly activates cholinergic motor neurons to evoke contractions that improve gastric emptying. NGES stimulation superimposes on spontaneous electromechanical activity to generate coordinated propagating contractions. In contrast, the most commonly applied form of gastric electrical stimulation (Enterra), employs paired pulses that stimulate vagal afferent pathways to reduce symptoms of nausea and vomiting, but does not enhance emptying. This review examines the evolution and implementation of NGES, focusing on its potential role as a treatment option to enhance gastric propulsion in gastroparesis and delayed gastric conduit emptying. While initial acute animal studies have shown promising results, continued development of the technology and refinement of stimulation protocols through chronic experiments remains essential for successful clinical translation.
- Keywords
- Delayed gastric conduit emptying; Electric stimulation therapy; Gastrointestinal motility; Stomach physiology
- Department(s)
- Surgical Oncology
- Publisher's Version
- https://doi.org/10.5056/jnm25106
- Open Access at Publisher's Site
https://doi.org/10.5056/jnm25106- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-01-23 05:48:32
Last Modified: 2026-01-23 05:50:32