Applying Radiomics to Predict Outcomes in Patients with High-Grade Retroperitoneal Sarcoma Treated with Preoperative Radiotherapy

Shahnam, A; Hardcastle, N; Gyorki, DE; Ingley, KM; Tran, K; Mitchell, C; Chander, S; Chu, J; Henderson, M; Herschtal, A; Bressel, M; Lewin, J

Author(s): Shahnam, A; Hardcastle, N; Gyorki, DE; Ingley, KM; Tran, K; Mitchell, C; Chander, S; Chu, J; Henderson, M; Herschtal, A; Bressel, M; Lewin, J;
Details: Publication Year 2025-12-15,Volume 11,Issue #12,Page 450
Journal Title: Journal of Imaging
Publication Type: Research article
Abstract: Retroperitoneal sarcomas (RPS) are rare tumours, primarily treated with surgical resection. However, recurrences are frequent. Combining clinical factors with CT-derived radiomic features could enhance treatment stratification and personalization. This study aims to assess whether radiomic features provide additional prognostic value beyond clinicopathological features in patients with high-risk RPS treated with preoperative radiotherapy. This retrospective study included patients aged 18 or older with non-recurrent and non-metastatic RPS treated with preoperative radiotherapy between 2008 and 2016. Hazard ratios (HR) were calculated using Cox proportional hazards regression to assess the impact of clinical and radiomic features on time to event outcomes. Predictive accuracy was assessed with c-statistics. Radiomic analysis was performed on the high-risk group (undifferentiated pleomorphic sarcoma, well-differentiated/de-differentiated liposarcoma or grade 2/3 leiomyosarcoma). Seventy-two patients were included, with a median follow-up of 3.7 years, the 5-year overall survival (OS) was 67%. Multivariable analysis showed older age (HR: 1.3 per 5-year increase, p = 0.04), grade 3 (HR: 180.3, p = 0.02), and larger tumours (HR: 4.0 per 10 cm increase, p = 0.02) predicted worse OS. In the higher-risk group, the c-statistic for the clinical model was 0.59 (time to distant metastasis (TDM)) and 0.56 (OS). Among 27 radiomic features, kurtosis improved OS prediction (c-statistic 0.69, p = 0.013), and Neighbourhood Gray-Tone Difference Matrix (NGTDM) busyness improved it to 0.73 (p = 0.036). Kurtosis also improved TDM prediction (c-statistic 0.72, p = 0.023). Radiomic features may complement clinicopathological factors in predicting overall survival and time to distant metastasis in high-risk retroperitoneal sarcoma. These exploratory findings warrant validation in larger, multi-institutional studies.
Keywords: predictive model; radiomics; retroperitoneal sarcomas
Department(s): Medical Oncology; Physical Sciences; Surgical Oncology; Radiation Oncology; Pathology; Biostatistics and Clinical Trials; AYA Cancer Service
Publisher's Version: https://doi.org/10.3390/jimaging11120450
Open Access at Publisher's Site: https://doi.org/10.3390/jimaging11120450
Terms of Use/Rights Notice: Refer to copyright notice on published article.

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