Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia-A Two-Case Series of a Diagnostically Challenging Presentation
- Author(s)
- Narula, M; Mahar, PD; Tan, EWH; Singh, N; Lade, S; Prince, HM; McCormack, C;
- Journal Title
- Australasian Journal of Dermatology
- Publication Type
- Online publication before print
- Abstract
- BACKGROUND/OBJECTIVES: Cutaneous manifestations of Waldenstrom's macroglobulinaemia (WM), a rare B-cell lymphoproliferative disorder, present a diagnostic challenge. The intent of this article is to raise awareness to clinicians of a potentially overlooked condition, particularly in the context of patients with a monoclonal IgM paraproteinaemia, but also to describe the diagnostic complexity of the disease from a clinicopathological perspective. METHODS: We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM. RESULTS: Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non-tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression. CONCLUSION: The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia.
- Department(s)
- Pathology; Haematology; Surgical Oncology
- Publisher's Version
- https://doi.org/10.1111/ajd.70021
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-01-23 11:58:23
Last Modified: 2026-01-23 12:00:54