A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials
- Author(s)
- Potter, S; Avery, K; Ahmed, R; de Boniface, J; Chatterjee, S; Dodwell, D; Dubsky, P; Federmann, J; Finestone, S; Gnant, M; Hlauschek, D; Iwata, H; Jiang, MY; Kaidar-Person, O; Lee, HB; MacKenzie, M; Meyn, A; Poortmans, P; Poulakaki, F; Richardson, AL; Sepulveda, KA; Spillane, AJ; Thompson, AM; Werutsky, G; Wittmann, P; Wright, JL; Zdenkowski, N; Cowan, K; McIntosh, SA; PRECEDENT Study Group;
- Journal Title
- NPJ Breast Cancer
- Publication Type
- Research article
- Abstract
- Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.
- Department(s)
- Cancer Imaging; Radiation Oncology
- Publisher's Version
- https://doi.org/10.1038/s41523-025-00824-w
- Open Access at Publisher's Site
https://doi.org/10.1038/s41523-025-00824-w- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-01-16 02:13:48
Last Modified: 2026-01-16 02:14:35