Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: Implications for surgical and clinical outcomes
Details
Publication Year 2023-06-20,Volume 4,Issue #6,Page 101055
Journal Title
Cell Reports Medicine
Publication Type
Research article
Abstract
Limited evidence exists on the impact of spatial and temporal heterogeneity of high-grade serous ovarian cancer (HGSOC) on tumor evolution, clinical outcomes, and surgical operability. We perform systematic multi-site tumor mapping at presentation and matched relapse from 49 high-tumor-burden patients, operated up front. From SNP array-derived copy-number data, we categorize dendrograms representing tumor clonal evolution as sympodial or dichotomous, noting most chemo-resistant patients favor simpler sympodial evolution. Three distinct tumor evolutionary patterns from primary to relapse are identified, demonstrating recurrent disease may emerge from pre-existing or newly detected clones. Crucially, we identify spatial heterogeneity for clinically actionable homologous recombination deficiency scores and for poor prognosis biomarkers CCNE1 and MYC. Copy-number signature, phenotypic, proteomic, and proliferative-index heterogeneity further highlight HGSOC complexity. This study explores HGSOC evolution and dissemination across space and time, its impact on optimal surgical cytoreductive effort and clinical outcomes, and its consequences for clinical decision-making.
Publisher
Cell Press
Keywords
Female; Humans; *Ovarian Neoplasms/genetics/surgery/pathology; Proteomics; Neoplasm Recurrence, Local/genetics; Cyclin E1; Hrd; cytoreductive surgery; high-grade serous ovarian cancer; homologous recombination deficiency score; spatial and temporal heterogeneity; tumor evolution
Department(s)
Laboratory Research
PubMed ID
37220750
Open Access at Publisher's Site
https://doi.org/10.1016/j.xcrm.2023.101055
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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Last Modified: 2023-09-12 07:44:44

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