Flicking the switch for B-cell development
- Journal Title
- Genes & Development
- Publication Type
- Online publication before print
- Abstract
- The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to allow the ordered expression of genes essential for B-cell development. In this issue of Genes & Development, Tingvall-Gustafsson and colleagues (doi:10.1101/gad.353002.125) have investigated the interplay of these transcriptional regulators with the chromatin state of developing lymphocytes at single-cell resolution. They pinpoint a rare population of progenitors where this epigenetic reprogramming occurs to simultaneously repress the expression of lineage-inappropriate genes and activate the B-cell program.
- Keywords
- B-lymphocytes; epigenetics; transcription
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.1101/gad.353397.125
- Open Access at Publisher's Site
https://doi.org/10.1101/gad.353397.125- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-01-08 04:40:50
Last Modified: 2026-01-08 04:41:02