Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS (iwMDS) Of the International Consortium for MDS (icMDS)
Journal Title
Blood Reviews
Publication Type
Review
Abstract
Biological events that contribute to the pathogenesis of myelodysplastic syndromes/neoplasms (MDS) are becoming increasingly characterized and are being translated into rationally designed therapeutic strategies. Herein, we provide updates from the first International Workshop on MDS (iwMDS) of the International Consortium for MDS (icMDS) detailing recent advances in understanding the genetic landscape of MDS, including germline predisposition, epigenetic and immune dysregulation, the complexities of clonal hematopoiesis progression to MDS, as well as novel animal models of the disease. Connected to this progress is the development of novel therapies targeting specific molecular alterations, the innate immune system, and immune checkpoint inhibitors. While some of these agents have entered clinical trials (e.g., splicing modulators, IRAK1/4 inhibitors, anti-CD47 and anti-TIM3 antibodies, and cellular therapies), none have been approved for MDS. Additional preclinical and clinical work is needed to develop a truly individualized approach to the care of MDS patients.
Publisher
Elsevier
Keywords
Animals; Humans; *Neoplasms; *Myelodysplastic Syndromes/etiology/therapy; Epigenomics; Cell- and Tissue-Based Therapy; Protein Processing, Post-Translational; Animal models; Genetics; Immunology; Mds; Myelodysplastic syndrome; Novel therapies
Department(s)
Clinical Haematology
PubMed ID
36934059
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-09-12 07:43:57
Last Modified: 2024-07-09 06:18:31

© 2024 The Walter and Eliza Hall Institute of Medical Research. Access to this website is subject to our Privacy Policy and Terms of Use

An error has occurred. This application may no longer respond until reloaded. Reload 🗙