Disseminated Invasive Mucormycosis Infection Following Autologous Stem Cell Transplantation for Diffuse Large B-Cell Lymphoma
- Author(s)
- Scheffer Cliff, ER; Reynolds, G; Grigg, A;
- Details
- Publication Year 2023-06,Volume 5,Issue #2-3,Page 71-77
- Journal Title
- Clinical Hematology International
- Publication Type
- Case report
- Abstract
- Invasive fungal infections (IFI) are challenging to predict, diagnose and treat, and are associated with a particularly high mortality among patients with hematological malignancies. They are relatively uncommon in patients with lymphoma, compared with those with acute leukemia or undergoing allogeneic transplantation. We present a patient, autografted for recurrent lymphoma, with fever and refractory diarrhea persisting post engraftment, eventually attributable to disseminated mucor infection. This case illustrates the challenge of timely diagnosis and initiation of treatment for IFI in lymphoma patients, who do not routinely receive antifungal prophylaxis, and the importance of aggressive investigation and symptom-directed tissue sampling for evidence of IFI in febrile immunocompromised hosts not responding to broad-spectrum antibiotics.
- Publisher
- Springer Nature
- Keywords
- Autologous stem cell transplant; Invasive fungal infection; Lymphoma; Mucor; Mucormycosis
- Department(s)
- Infectious Diseases
- PubMed ID
- 36750525
- Publisher's Version
- https://doi.org/10.1007/s44228-023-00031-z
- Open Access at Publisher's Site
https://doi.org/10.1007/s44228-023-00031-z- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-09-12 01:58:44
Last Modified: 2023-09-12 01:59:21