Immune mediated colitis: a surgical perspective

Le, KDR; Choy, KT; Roth, S; Heriot, AG; Kong, JCH

Author(s): Le, KDR; Choy, KT; Roth, S; Heriot, AG; Kong, JCH;
Details: Publication Year 2023-06,Volume 93,Issue #6,Page 1495-1502
Journal Title: ANZ Journal of Surgery
Publication Type: Review
Abstract: BACKGROUND: This study aims to review and summarize the current up to date literature that explore the current treatment approaches to immune mediated colitis and the role of surgical specialties in the landscape of management. METHODS: A narrative review of papers was performed following a literature search through Medline, EMBASE and Cochrane Central databases pertaining to immune mediated colitis as an adverse event of cancer immunotherapy. RESULTS: Current guidelines for the diagnosis and treatment of immune mediated colitis mirror the approach to the workup of inflammatory bowel disease and guided by treating oncology and gastroenterology specialties. Immune mediated colitis however relies on surgical specific skills as a consequence of obtaining a diagnosis as well as in the management of complications that may arise. CONCLUSION: Immune mediate colitis management has largely been under the purview of medical specialties. This review explores the current landscape of managing immune mediated colitis from a surgical perspective and highlights key areas in which surgeons can engage in the multidisciplinary care of this condition. To facilitate prompt diagnosis and management of immune-mediated colitis, there is an increasing necessity for surgeons to become familiar with the latest multidisciplinary approaches and recommendations.
Publisher: Wiley
Keywords: Humans; Antibodies, Monoclonal/adverse effects; *Colitis/diagnosis/etiology/surgery; *Inflammatory Bowel Diseases/surgery; checkpoint inhibitor induced colitis; checkpoint inhibitors; colon; cytotoxic T-lymphocyte associated antigen 4; immune checkpoint inhibitors; immune mediated colitis; immune related adverse events; immune therapy; immunotherapy; immunotherapy induced colitis; programmed cell death protein 1; programmed death ligand 1
Department(s): Surgical Oncology; Laboratory Research
PubMed ID: 37088921
Publisher's Version: https://doi.org/10.1111/ans.18485
Open Access at Publisher's Site: https://doi.org/10.1111/ans.18485
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-09-12 01:58:42

Last Modified: 2023-09-12 01:59:21