Antifungal hypersensitivity reactions and cross-reactivity patterns
- Author(s)
- Copaescu, AM; Phillips, EJ; Trubiano, JA;
- Details
- Publication Year 2021-12,Volume 34,Issue #6,Page 559-572
- Journal Title
- Current Opinion in Infectious Diseases
- Publication Type
- Review
- Abstract
- PURPOSE OF REVIEW: The goal of this article is to provide an updated understanding and evidence-based approach where possible for antifungal hypersensitivity. This includes recognition of clinical phenotype, implications for cross-reactivity and diagnostic, and management strategy for immediate and delayed hypersensitivity reactions. RECENT FINDINGS: Antifungal hypersensitivity reactions can be classified according to their latency (immediate or delayed) and clinical phenotype. The majority of the cases described in the literature are delayed T-cell mediated reactions of various severities but immediate reactions consistent with non-Immunoglobulin E (IgE)-mediated mast cell activation and IgE-mediated reactions have also been described. Ancillary information such as skin testing, drug challenge and ex vivo experimental approaches can aid causality assessments and inform antifungal class cross-reactivity, which help optimize antifungal prescribing and stewardship. SUMMARY: This review will update the clinician on mechanisms of drug hypersensitivity as well as providing a structured approach to the recognition, diagnosis and management of antifungal hypersensitivity reaction.
- Keywords
- *Antifungal Agents/adverse effects; Cross Reactions; *Drug Hypersensitivity/diagnosis/etiology; Humans; Immunoglobulin E; Skin Tests
- Department(s)
- Infectious Diseases
- PubMed ID
- 34693920
- Publisher's Version
- https://doi.org/10.1097/QCO.0000000000000786
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-09-05 01:45:03
Last Modified: 2025-09-05 01:46:46