The high (I)COSt of costimulation for exhausted T cells
- Author(s)
- de Menezes, MN; Parish, IA;
- Details
- Publication Year 2025-08-12,Volume 58,Issue #8,Page 1882-1884
- Journal Title
- Immunity
- Publication Type
- Commentary
- Abstract
- ICOS agonists are being investigated for cancer immunotherapy based on the idea that they will reinvigorate exhausted CD8(+) T cell anti-cancer immunity. Humblin et al. unexpectedly find the opposite-that CD8(+) T cell-intrinsic ICOS expression restrains rather than promotes exhausted CD8(+) T cell function in both chronic viral infection and tumor models.
- Publisher
- Cell Press
- Keywords
- *CD8-Positive T-Lymphocytes/immunology; *Inducible T-Cell Co-Stimulator Protein/immunology/metabolism/agonists; Humans; Animals; *Neoplasms/immunology/therapy; Immunotherapy/methods; Lymphocyte Activation/immunology; Mice
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2025.07.010
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-08-28 05:52:26
Last Modified: 2025-08-28 05:52:35