Advances in Lung Cancer Basic and Translational Research in 2025 - Overview and Perspectives Focusing on NSCLC

Mascaux, C; Sen, T; Sanchez-Cespedes, M; Ortiz-Cuaran, S; Boss&#233;, Y; Dammeijer, F; Cavic, M; Barr, MP; Arulananda, S; Armisen, R; Berger, AH; Bianchi, F; Carbone, DP; Cerciello, F; Lockwood, WW; Mitsudomi, T; Ohara, S; Politi, K; Qin, S; Roisman, LC; Samstein, R; Skoulidis, F; Tan, AC; Thomas, A; Zhang, J; Wynes, MW; John, T; Tsao, MS; IASLC Basic and Translational Science Committee

Author(s): Mascaux, C; Sen, T; Sanchez-Cespedes, M; Ortiz-Cuaran, S; Bossé, Y; Dammeijer, F; Cavic, M; Barr, MP; Arulananda, S; Armisen, R; Berger, AH; Bianchi, F; Carbone, DP; Cerciello, F; Lockwood, WW; Mitsudomi, T; Ohara, S; Politi, K; Qin, S; Roisman, LC; Samstein, R; Skoulidis, F; Tan, AC; Thomas, A; Zhang, J; Wynes, MW; John, T; Tsao, MS; IASLC Basic and Translational Science Committee;
Details: Publication Year 2025-10,Volume 20,Issue #10,Page 1369-1391
Journal Title: Journal of Thoracic Oncology
Publication Type: Review
Abstract: Basic and translational research in lung cancer is a rapidly evolving field with a transformational impact on early detection, diagnosis, therapeutic development, and personalization of care. Recent advances have greatly increased our understanding of the molecular genomics, proteomics, pathogenesis, and cellular biology of this deadly malignancy. The International Association for the Study of Lung Cancer (IASLC) recently formed a Basic and Translational Science (BaTS) Committee to further enhance the scientific leadership of IASLC in thoracic cancer research. This review by members of the committee highlights the breadth of current research in NSCLC, with a focus on molecular risk factors and processes in tumorigenesis, heterogeneity, phenotypic plasticity, metabolic reprogramming, immunobiology, the immune microenvironment, and microbiome. This review also identifies future research areas that may lead to further improvement in survival outcomes and curative therapies especially for patients with advanced NSCLC.
Publisher: Elsevier
Keywords: Humans; *Lung Neoplasms/pathology/therapy; *Carcinoma, Non-Small-Cell Lung/pathology/therapy; *Translational Research, Biomedical; Cancer metabolism; Early lung cancer; Genomics; Immune microenvironment; State of Science; Tumor heterogeneity
Department(s): Medical Oncology
Publisher's Version: https://doi.org/10.1016/j.jtho.2025.05.024
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-07-31 04:18:38

Last Modified: 2025-11-13 02:49:18