A change in surgical margin: do wider surgical margins lead to decreased rates of local recurrence in T1 and T2 oral tongue cancer?
Details
Publication Year 2023-01,Volume 52,Issue #1,Page 19-25
Journal Title
International Journal of Oral and Maxillofacial Surgery
Publication Type
Research article
Abstract
The purpose of this study was to assess the impact of a change in macroscopic/surgical margin width upon histological margins and loco-regional failure in early oral tongue squamous cell carcinoma (OTSCC). In 2009, the surgical margin protocol was increased from 10 mm to 15 mm. A retrospective review was performed of all patients who underwent treatment for early OTSCC between 2009 and 2016 with a 15-mm surgical margin (n = 142), and these patients were compared to those treated between 1999 and 2008 with a 10-mm surgical margin (n = 78). There was a significant increase in the rate of clear histological margins (P < 0.001). The rates of close (P = 0.002) and involved (P < 0.001) histological margins decreased significantly. There were significant reductions in local (P < 0.001) and regional (P < 0.001) recurrence rates. This study demonstrated that a surgical margin of 15 mm delivered significantly lower rates of close/involved histological margins and improved local and regional disease recurrence in early OTSCC when compared with a surgical margin of 10 mm.
Publisher
Elsevier
Keywords
Humans; *Tongue Neoplasms/surgery/pathology; Margins of Excision; *Carcinoma, Squamous Cell/surgery/pathology; Neoplasm Recurrence, Local/pathology; *Mouth Neoplasms/pathology; Retrospective Studies; Neoplasm Staging; Local neoplasm recurrence; Oral tongue squamous cell carcinoma; Recurrence; Surgical oncology
Department(s)
Radiation Oncology
PubMed ID
35610164
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-04-06 06:53:42
Last Modified: 2024-07-09 05:20:38

© 2024 The Walter and Eliza Hall Institute of Medical Research. Access to this website is subject to our Privacy Policy and Terms of Use

An error has occurred. This application may no longer respond until reloaded. Reload 🗙