A change in surgical margin: do wider surgical margins lead to decreased rates of local recurrence in T1 and T2 oral tongue cancer?

Daniell, JR; Rowe, D; Wiesenfeld, D; McDowell, L; Hall, KA; Nastri, A; Iseli, TA; Wong, T

Author(s): Daniell, JR; Rowe, D; Wiesenfeld, D; McDowell, L; Hall, KA; Nastri, A; Iseli, TA; Wong, T;
Details: Publication Year 2023-01,Volume 52,Issue #1,Page 19-25
Journal Title: International Journal of Oral and Maxillofacial Surgery
Publication Type: Research article
Abstract: The purpose of this study was to assess the impact of a change in macroscopic/surgical margin width upon histological margins and loco-regional failure in early oral tongue squamous cell carcinoma (OTSCC). In 2009, the surgical margin protocol was increased from 10 mm to 15 mm. A retrospective review was performed of all patients who underwent treatment for early OTSCC between 2009 and 2016 with a 15-mm surgical margin (n = 142), and these patients were compared to those treated between 1999 and 2008 with a 10-mm surgical margin (n = 78). There was a significant increase in the rate of clear histological margins (P < 0.001). The rates of close (P = 0.002) and involved (P < 0.001) histological margins decreased significantly. There were significant reductions in local (P < 0.001) and regional (P < 0.001) recurrence rates. This study demonstrated that a surgical margin of 15 mm delivered significantly lower rates of close/involved histological margins and improved local and regional disease recurrence in early OTSCC when compared with a surgical margin of 10 mm.
Publisher: Elsevier
Keywords: Humans; *Tongue Neoplasms/surgery/pathology; Margins of Excision; *Carcinoma, Squamous Cell/surgery/pathology; Neoplasm Recurrence, Local/pathology; *Mouth Neoplasms/pathology; Retrospective Studies; Neoplasm Staging; Local neoplasm recurrence; Oral tongue squamous cell carcinoma; Recurrence; Surgical oncology
Department(s): Radiation Oncology
PubMed ID: 35610164
Publisher's Version: https://doi.org/10.1016/j.ijom.2022.04.008
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-04-06 06:53:42

Last Modified: 2024-07-09 05:20:38