Cryptic but critical: non-canonical antigens in cancer immunotherapy
- Author(s)
- Goncalves, G; Dolcetti, R; Ooi, JD; Faridi, P;
- Details
- Publication Year 2025-07,Volume 46,Issue #7,Page 499-501
- Journal Title
- Trends in Immunology
- Publication Type
- Commentary
- Abstract
- Two recent studies, by Ely et al. and Apavaloaei et al., revealed that non-canonical antigens derived from unmutated, noncoding regions dominate the immunopeptidome of many cancers. Here, we discuss how this challenges conventional mutation-centric immunotherapies and highlight emerging strategies, including cryptic antigen- and TCR-targeted vaccines, as promising new clinically relevant paths in personalised and off-the-shelf cancer immunotherapy.
- Publisher
- Cell Press
- Keywords
- Humans; *Neoplasms/therapy/immunology; *Antigens, Neoplasm/immunology/genetics; *Immunotherapy/methods; *Cancer Vaccines/immunology/therapeutic use; Animals; Receptors, Antigen, T-Cell/immunology/metabolism; Mutation
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.it.2025.06.002
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-07-25 07:49:14
Last Modified: 2025-07-29 05:57:05