Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy and haemopoietic stem cell transplant recipients, 2021
- Author(s)
- Chau, MM; Daveson, K; Alffenaar, JWC; Gwee, A; Ho, SA; Marriott, DJE; Trubiano, JA; Zhao, J; Roberts, JA; Australasian Antifungal Guidelines Steering Committee;
- Details
- Publication Year 2021-11,Volume 51,Issue #Suppl 7,Page 37-66
- Journal Title
- Internal Medicine Journal
- Publication Type
- Guideline
- Abstract
- Antifungal agents can have complex dosing and the potential for drug interaction, both of which can lead to subtherapeutic antifungal drug concentrations and poorer clinical outcomes for patients with haematological malignancy and haemopoietic stem cell transplant recipients. Antifungal agents can also be associated with significant toxicities when drug concentrations are too high. Suboptimal dosing can be minimised by clinical assessment, laboratory monitoring, avoidance of interacting drugs, and dose modification. Therapeutic drug monitoring (TDM) plays an increasingly important role in antifungal therapy, particularly for antifungal agents that have an established exposure-response relationship with either a narrow therapeutic window, large dose-exposure variability, cytochrome P450 gene polymorphism affecting drug metabolism, the presence of antifungal drug interactions or unexpected toxicity, and/or concerns for non-compliance or inadequate absorption of oral antifungals. These guidelines provide recommendations on antifungal drug monitoring and TDM-guided dosing adjustment for selected antifungal agents, and include suggested resources for identifying and analysing antifungal drug interactions. Recommended competencies for optimal interpretation of antifungal TDM and dose recommendations are also provided.
- Keywords
- Antifungal Agents; Drug Interactions; Drug Monitoring; *Hematologic Neoplasms/drug therapy; *Hematopoietic Stem Cell Transplantation; Humans; antifungal therapy; drug interaction; pharmacogenomics; therapeutic drug monitoring; toxicity
- Department(s)
- Infectious Diseases
- PubMed ID
- 34937141
- Publisher's Version
- https://doi.org/10.1111/imj.15587
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-06-20 08:03:15
Last Modified: 2025-06-20 08:04:25