Tumour-infiltrating lymphocytes in non-invasive breast cancer: A systematic review and meta-analysis
- Author(s)
- Caparica, R; Bruzzone, M; Agostinetto, E; Franzoi, MA; Ceppi, M; Radosevic-Robin, N; Penault-Llorca, F; Willard-Gallo, K; Loi, S; Salgado, R; de Azambuja, E;
- Journal Title
- Breast
- Publication Type
- Review
- Abstract
- BACKGROUND: The role of tumour infiltrating lymphocytes (TILs) as a biomarker in non-invasive breast cancer is unclear. This meta-analysis assessed the prognostic impact of TIL levels in patients with non-invasive breast cancer. METHODS: Systematic literature search was performed to identify studies assessing local recurrence in patients with non-invasive breast cancer according to TIL levels (high vs. low). Subgroup analyses per local recurrence (invasive and non-invasive) were performed. Secondary objectives were the association between TIL levels and non-invasive breast cancer subtypes, age, grade and necrosis. Odds ratios (ORs) and 95% confidence intervals (CI) were extracted from each study and a pooled analysis was conducted with random-effect model. RESULTS: Seven studies (N = 3437) were included in the present meta-analysis. High-TILs were associated with a higher likelihood of local recurrence (invasive or non-invasive, N = 2941; OR 2.05; 95%CI, 1.03-4.08; p = 0.042), although with a lower likelihood of invasive local recurrence (N = 1722; OR 0.69; 95%CI, 0.49-0.99; p = 0.042). High-TIL levels were associated with triple-negative (OR 3.84; 95%CI, 2.23-6.61; p < 0.001) and HER2-positive (OR 6.27; 95%CI, 4.93-7.97; p < 0.001) subtypes, high grade (OR 5.15; 95%CI, 3.69-7.19; p < 0.001) and necrosis (OR 3.09; 95%CI, 2.33-4.10; p < 0.001). CONCLUSIONS: High-TIL levels were associated with more aggressive tumours, a higher likelihood of local recurrence (invasive or non-invasive) but a lower likelihood of invasive local recurrence in patients with non-invasive breast cancer.
- Keywords
- *Breast Neoplasms; Female; Humans; Lymphocytes, Tumor-Infiltrating; Neoplasm Recurrence, Local; Prognosis; Receptor, ErbB-2; *Triple Negative Breast Neoplasms; "Local recurrence"; "Non-invasive breast cancer"; "Tumour infiltrating lymphocytes"
- Department(s)
- Medical Oncology; Laboratory Research
- PubMed ID
- 34273666
- Publisher's Version
- https://doi.org/10.1016/j.breast.2021.07.007
- Open Access at Publisher's Site
https://doi.org/10.1016/j.breast.2021.07.007- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-06-20 03:31:55
Last Modified: 2025-06-20 03:33:48