18F-Fluorothymidine PET for Functional Response Assessment Following Radiation Therapy for Extramedullary Hematopoiesis
- Author(s)
- Campbell, BA; Callahan, J; Cole-Sinclair, M; MacManus, M; Hofman, MS;
- Details
- Publication Year 2021,Volume 46,Issue #9,Page e454-e457
- Journal Title
- Clinical Nuclear Medicine
- Publication Type
- Case report
- Abstract
- As a marker of cellular proliferation, 18F-fluorothymidine (FLT) PET can detect the distribution of proliferating hematopoiesis and has an emerging role in the investigation of hematopoietic disorders. These images demonstrate the novel utility of 18F-FLT PET for imaging sites of extramedullary hematopoiesis (EMH) in a patient with Chuvash-type polycythemia and suggest a role for 18F-FLT PET in response assessment following radiotherapy. Further, the discordant response observed in the irradiated marrow and sites of EMH is a unique discovery, possibly suggesting the influence of the microenvironment favoring more rapid recovery of proliferative function within EMH sites.
- Keywords
- Bone Marrow/diagnostic imaging; Dideoxynucleosides; *Hematopoiesis, Extramedullary; Humans; Positron-Emission Tomography
- Department(s)
- Radiation Oncology; Cancer Imaging
- PubMed ID
- 33661206
- Publisher's Version
- https://doi.org/10.1097/RLU.0000000000003566
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-06-20 03:31:53
Last Modified: 2025-06-20 03:33:48