Analgesic use and the risk of renal cell carcinoma - Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study
- Author(s)
- Bruinsma, FJ; Jordan, S; Bassett, JK; Severi, G; MacInnis, RJ; Walsh, J; Aitken, T; Jenkins, M; Carroll, R; Jefford, M; Davis, ID; Tucker, K; Dudding-Byth, T; English, DR; Giles, GG; Winship, I; Milne, RL;
- Journal Title
- Cancer Epidemiology
- Publication Type
- Research article
- Abstract
- PURPOSE: The incidence of renal cell carcinoma (RCC) is rising. Use of analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol may affect renal function. The aim of this study was to assess associations between analgesic use and risk of RCC. METHODS: A population-based case-control family design was used. Cases were recruited via two Australian state cancer registries. Controls were siblings or partners of cases. Analgesic use was captured by self-completed questionnaire. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for RCC risk associated with regular analgesic use (at least 5 times per month for 6 months or more) and duration and frequency of use. RESULTS: The analysis included 1064 cases and 724 controls. Regular use of paracetamol was associated with an increased risk of RCC (OR 1.41, 95%CI 1.13-1.77). Regular use of NSAIDs was associated with increased risk of RCC for women (OR 1.71, 95% CI 1.23-2.39) but not men (OR 0.83, 95% CI 0.58-1.18; p-interaction=0.003). There was no evidence of a dose-response for duration of use of paracetamol (linear trend p = 0.77) and weak evidence for non- aspirin NSAID use by women (linear trend p = 0.054). CONCLUSION: This study found that regular use of paracetamol was associated with increased risk of RCC. NSAID use was associated with increased risk only for women.
- Keywords
- Acetaminophen/adverse effects; Analgesics/adverse effects; Australia/epidemiology; *Carcinoma, Renal Cell/chemically induced/epidemiology; Female; Humans; *Kidney Neoplasms/chemically induced/epidemiology; Analgesic use; Epidemiology; NSAIDs; Paracetamol; Renal cell carcinoma
- Department(s)
- Medical Oncology; Health Services Research; Australian Cancer Survivorship Centre
- PubMed ID
- 34562747
- Publisher's Version
- https://doi.org/10.1016/j.canep.2021.102036
- Open Access at Publisher's Site
https://doi.org/10.1016/j.canep.2021.102036- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-06-19 06:51:05
Last Modified: 2025-06-19 06:51:41