Antibody-Drug Conjugates for Lung Cancer: Payloads and Progress
Journal Title
American Society of Clinical Oncology Educational Book
Publication Type
Review
Abstract
Antibody Drug Conjugates (ADCs) are a novel class of therapeutic that structurally comprise an antibody directed at a tumor epitope connected via a linker to a cytotoxic payload that have shown significant antitumor activity across a range of malignancies including lung cancer. In this article we review the pharmacology of ADCs, describe results of trials with ADCs directed at targets in lung cancer including Trophoblast cell-surface antigen 2(TROP2), HER3, MET, Carcinoembryonic antigen-related cell adhesion molecular 5(CECAM-5) and HER2. Trastuzumab Deruxtecan (also known as DS-8201a or T-DXd) an ADC directed at HER2 recently became the first ADC to receive FDA approval in lung cancer, on the basis of its activity in tumors with HER2 mutations, demonstrated in the Destiny-Lung01 and Lung02 trials.
Publisher
American Society of Clinical Oncology
Keywords
Humans; Antibodies, Monoclonal, Humanized/therapeutic use; Trastuzumab; *Antineoplastic Agents/therapeutic use; Camptothecin/pharmacology; *Lung Neoplasms/drug therapy; *Immunoconjugates/therapeutic use; Receptor, ErbB-2/genetics
Department(s)
Medical Oncology
PubMed ID
37163707
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-09-05 06:33:26
Last Modified: 2024-07-16 04:24:20

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