Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis
Details
Publication Year 2021-02,Volume 11,Issue #2,Page 249
Journal Title
Biomolecules
Publication Type
Review
Abstract
Abstract: Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including non-coding RNAs which are a category of RNAs that do not encode proteins and have important regulatory functions at transcriptional and post-transcriptional levels. Non-coding RNAs can be encapsulated in extracellular vesicles called exosomes which are secreted by tumour cells or other cells in the tumour microenvironment and can then be taken up by the endothelial cells of blood vessels and lymphatic vessels. The "delivery" of these non-coding RNAs to endothelial cells in tumours can facilitate tumour angiogenesis and lymphangiogenesis. Here we review recent findings about exosomal non-coding RNAs, specifically microRNAs and long non-coding RNAs, which regulate tumour angiogenesis and lymphangiogenesis in cancer. We then focus on the potential use of these molecules as cancer biomarkers and opportunities for exploiting ncRNAs for the treatment of cancer.
Keywords
Exosomes/*metabolism; *Gene Expression Regulation, Neoplastic; Humans; Lymphangiogenesis/*genetics; Neoplasms/*blood supply/*pathology; Neovascularization, Pathologic/*genetics; RNA, Untranslated/*metabolism
Department(s)
Laboratory Research
PubMed ID
33572413
Open Access at Publisher's Site
https://doi.org/10.3390/biom11020249
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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