Interorgan communication in development and cancer
- Author(s)
- Alvarez-Ochoa, E; Froldi, F; Cheng, LY;
- Details
- Publication Year 2021-07,Volume 10,Issue #4,Page e394
- Journal Title
- Wiley Interdisciplinary Reviews Developmental Biology
- Publication Type
- Review
- Abstract
- Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells depend on the outcome of their interaction with the immune system and peripheral tissues. In this review, we outline recent studies in Drosophila, which have enabled an improved understanding of the complex crosstalk between organs in the context of both organismal and tumor growth. We argue that Drosophila is a powerful model organism for studying these interactions, and these studies have the potential for improving our understanding of signaling pathways and candidate factors that mediate this conserved interorgan crosstalk. This article is categorized under: Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing Early Embryonic Development > Development to the Basic Body Plan Invertebrate Organogenesis > Flies.
- Keywords
- Animals; *Communication; Drosophila/*growth & development; Drosophila Proteins/*metabolism; *Embryonic Development; Neoplasms/*pathology; *Organogenesis; Signal Transduction; organ growth; systemic growth; tumour growth | organ crosstalk | Drosophila melanogaster
- Department(s)
- Laboratory Research
- PubMed ID
- 32852143
- Publisher's Version
- https://doi.org/10.1002/wdev.394
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-23 04:02:53
Last Modified: 2025-05-23 04:04:10