Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis
- Author(s)
- Abo, YN; Curtis, N; Osowicki, J; Haeusler, G; Purcell, R; Kadambari, S; De Wachter, M; Vanden Driessche, K; Dekeyzer, S; Coleman, L; Crawford, N; Graham, S; Marais, B; Gwee, A;
- Details
- Publication Year 2021-10,Volume 10,Issue #12,Page 1087-1091
- Journal Title
- Journal of the Pediatric Infectious Diseases Society
- Publication Type
- Case report
- Abstract
- Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.
- Keywords
- Adrenal Cortex Hormones; *Antitubercular Agents/adverse effects; Child; Humans; Infliximab/adverse effects; Prospective Studies; *Tuberculosis, Central Nervous System/drug therapy
- Department(s)
- Infectious Diseases
- PubMed ID
- 34608937
- Publisher's Version
- https://doi.org/10.1093/jpids/piab094
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-16 07:57:40
Last Modified: 2025-05-16 07:58:33