Advances in Frontline Management of Peripheral T-cell Lymphoma
Details
Publication Year 2021-06,Volume 21,Issue #6,Page 368-378
Journal Title
Clinical Lymphoma, Myeloma & Leukemia
Publication Type
Review
Abstract
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphomas that are frequently associated with a poor prognosis. For many decades, the standard-of-care has been CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone)-based therapy, but it is well-recognized that survival outcomes are unsatisfactory, especially when compared with B-cell lymphomas. Major recent advances in cancer diagnosis and management have the potential to significantly improve PTCL outcomes. These include: (1) improved diagnostic techniques that incorporate molecular genetic data to further refine diagnosis and subtyping; (2) the development of novel agents; and (3) improved monitoring modalities, such as (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans and circulating tumor DNA. In this review, we aim to explore these 3 advances in the context of frontline management of PTCL.
Keywords
Biomarkers, Tumor; Clinical Decision-Making; Clinical Trials as Topic; Combined Modality Therapy/adverse effects/methods; Diagnosis, Differential; Diagnostic Imaging/methods; Disease Management; Humans; Lymphoma, T-Cell, Peripheral/diagnosis/etiology/mortality/*therapy; Molecular Diagnostic Techniques; Monitoring, Physiologic; Population Surveillance; Prognosis; Treatment Outcome; Disease monitoring; Hematopoietic stem cell transplantation; Molecular diagnostics; Novel agents; Radiotherapy
Department(s)
Haematology
PubMed ID
33610499
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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