PD-L1 expression as a prognostic marker in patients treated with chemotherapy for metastatic non-small-cell lung cancer
Details
Publication Year 2022-05,Volume 18,Issue #14,Page 1793-1799
Journal Title
Future Oncology
Publication Type
Review
Abstract
Background: In metastatic non-small-cell lung cancer (mNSCLC), PD-L1 expression is associated with benefit from immune checkpoint inhibitor (ICI) therapy. However, the significance of PD-L1 expression in chemotherapy-treated patients is uncertain. Methods: Using the chemotherapy control arm of first-line randomized trials, a meta-analysis of the association between efficacy outcomes and PD-L1 status was performed, stratified by assay due to inter-assay differences. Results: Across 12 trials and 4378 patients, overall survival (OS) was superior in high PD-L1 versus negative tumors and low versus negative according to 22C3/28-8 assays. When classified by SP142 assay, no significant difference in response or survival was seen between PD-L1 groups. Conclusion: In mNSCLC, high PD-L1-expressing tumors are associated with longer OS and improved objective rate when treated with chemotherapy. Inter-assay variability impacts outcome results.; Biomarkers are naturally occurring cancer traits that can predict certain events. PD-L1 expression is a biomarker used in advanced lung cancer to predict benefit from immunotherapy. However, the association between PD-L1expression and chemotherapy is unclear. The authors analyzed data from 14 large clinical trials and found that PD-L1 expression could also be used to define a type of lung cancer that responds better to chemotherapy.; eng
Keywords
Antineoplastic Combined Chemotherapy Protocols/adverse effects; B7-H1 Antigen/metabolism; *Carcinoma, Non-Small-Cell Lung/drug therapy/genetics; Humans; *Lung Neoplasms/drug therapy/genetics; Prognosis; Pd-l1; biomarkers; chemotherapy; metastatic cancer; non-small-cell lung cancer; prognostic markers
Department(s)
Medical Oncology
PubMed ID
35156837
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