Integrating Functional Imaging and Molecular Profiling for Optimal Treatment Selection in Neuroendocrine Neoplasms (NEN)

Kong, G; Boehm, E; Prall, O; Murray, WK; Tothill, RW; Michael, M

Author(s): Kong, G; Boehm, E; Prall, O; Murray, WK; Tothill, RW; Michael, M;
Details: Publication Year 2023-05,Volume 25,Issue #5,Page 465-478
Journal Title: Current Oncology Reports
Publication Type: Review
Abstract: PURPOSE OF REVIEW: Gastroenteropancreatic NEN (GEP-NEN) are group of malignancies with significant clinical, anatomical and molecular heterogeneity. High-grade GEP-NEN in particular present unique management challenges. RECENT FINDINGS: In the current era, multidisciplinary management with access to a combination of functional imaging and targeted molecular profiling can provide important disease characterisation, guide individualised management and improve patient outcome. Multiple treatment options are now available, and combination and novel therapies are being explored in clinical trials. Precision medicine is highly relevant for a heterogenous disease like NEN. The integration of dual-tracer functional PET/CT imaging, molecular histopathology and genomic data has the potential to be used to gain a more comprehensive understanding of an individual patient's disease biology for precision diagnosis, prognostication and optimal treatment allocation.
Publisher: Springer Nature
Keywords: Humans; Positron Emission Tomography Computed Tomography; *Gastrointestinal Neoplasms/diagnostic imaging/genetics/therapy; *Neuroendocrine Tumors/diagnostic imaging/genetics/therapy; *Pancreatic Neoplasms/diagnostic imaging/genetics/therapy; *Intestinal Neoplasms/diagnostic imaging/genetics/therapy; *Stomach Neoplasms/diagnostic imaging/genetics/therapy; Functional imaging; Genomics; Molecular profile; Neuroendocrine neoplasms (NEN); Neuroendocrine tumors (NET); Pet/ct
Department(s): Cancer Imaging; Pathology; Medical Oncology
PubMed ID: 36826704
Publisher's Version: https://doi.org/10.1007/s11912-023-01381-w
Open Access at Publisher's Site: https://doi.org/10.1007/s11912-023-01381-w
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-08-15 07:31:29

Last Modified: 2023-08-15 07:32:14