Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
- Author(s)
- Wall, I; Boulat, V; Shah, A; Blenman, KRM; Wu, Y; Alberts, E; Calado, DP; Salgado, R; Grigoriadis, A;
- Details
- Publication Year 2022-09-17,Volume 14,Issue #18,Page 4505
- Journal Title
- Cancers
- Publication Type
- Review
- Abstract
- During the anti-tumour response to breast cancer, the primary tumour, the peripheral blood, and the lymph nodes each play unique roles. Immunological features at each site reveal evidence of continuous immune cross-talk between them before, during and after treatment. As such, immune responses to breast cancer are found to be highly dynamic and truly systemic, integrating three distinct immune sites, complex cell-migration highways, as well as the temporal dimension of disease progression and treatment. In this review, we provide a connective summary of the dynamic immune environment triad of breast cancer. It is critical that future studies seek to establish dynamic immune profiles, constituting multiple sites, that capture the systemic immune response to breast cancer and define patient-selection parameters resulting in more significant overall responses and survival rates for breast cancer patients.
- Keywords
- breast cancer; lymph node; systemic immunity; triple-negative breast cancers
- Department(s)
- Laboratory Research
- PubMed ID
- 36139665
- Publisher's Version
- https://doi.org/10.3390/cancers14184505
- Open Access at Publisher's Site
https://doi.org/10.3390/cancers14184505- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-09 03:13:07
Last Modified: 2025-05-09 03:13:54