Chapter 7 - Transcriptional Regulation of Early B-Cell Development
- Journal Title
- In: Honjo, T., Reth, M., Radbruch, A., Alt, F., Martin, A. (eds). Molecular Biology of B Cells, 3rd edn
- Publication Type
- Book section
- Abstract
- The differentiation of B cells from multipotent haematopoietic progenitors is unique in that it requires the activation of a gene expression programme whose unfolding needs to be coordinated with the multiple steps in gene recombination required to generate and select B cells with a broad immunoglobulin repertoire. Interrogation of the transcriptional network has led to the identification and characterisation of a suite of transcription factors required for B-lineage development and has led to profound insights into the role that these regulatory proteins play during normal lymphopoiesis and in disease settings such as immunodeficiency and leukemia. In this chapter we provide an overview of transcriptional regulation of early B-cell development, highlighting the increasingly complex roles played by these transcription factors, both in isolation, and as part of a gene regulatory network, in orchestrating the cellular processes and genomic reorganisation required to generate functional B cells.
- Publisher
- Academic Press
- Keywords
- B cell; Differentiation; Gene regulation; Immunoglobulin recombination; Lineage specification; Transcription factors
- Department(s)
- Haematology
- Publisher's Version
- https://doi.org/10.1016/B978-0-323-95895-0.00014-3
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-01 08:11:39
Last Modified: 2025-05-01 08:12:28