18F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis

Seth, N; Seth, I; Bulloch, G; Siu, AHY; Guo, A; Chatterjee, R; MacManus, M; Donnan, L

Author(s): Seth, N; Seth, I; Bulloch, G; Siu, AHY; Guo, A; Chatterjee, R; MacManus, M; Donnan, L;
Details: Publication Year 2022-03,Volume 69,Issue #3,Page e29415
Journal Title: Pediatric Blood & Cancer
Publication Type: Review
Abstract: PURPOSE: The aim of this study was to evaluate the diagnostic accuracy of (18) -fluorodeoxyglucose-positron emission tomography ((18) F-FDG PET) and PET/computed tomography (PET/CT) in imaging primary and metastatic lesions in Ewing sarcoma (ES). METHODS: PubMed, Cochrane, Scopus, and Web of Science were searched for relevant studies. Data concerning (18) F-FDG PET/CT diagnostic accuracy were extracted and then analyzed using Open Meta-analyst software. Reported diagnostic accuracy outcomes included sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), and diagnostic odds ratio. RESULTS: Thirty-one studies with a total of 735 patients were included in this meta-analysis. The sensitivity and specificity of (18) F-FDG PET/CT were: 92.6% and 74.1% for total ES lesions, 96.7% and 68.3% for ES primary lesions, 76.1% and 92.4% for lung metastasis, 83.9% and 93.2% for bone metastasis, and 89.9% and 92.6% for ES recurrence, respectively. CONCLUSION: (18) F-FDG PET/CT is sensitive and accurate in diagnosing, staging, and detecting the recurrence of ES compared with non-PET imaging. It has high accuracy for diagnosing recurrence of ES in bone metastases; however, CT remains a superior diagnostic method for detecting lung metastasis.
Keywords: *Bone Neoplasms/pathology; Fluorodeoxyglucose F18; Humans; *Lung Neoplasms; *Neuroectodermal Tumors, Primitive, Peripheral; Positron Emission Tomography Computed Tomography/methods; Positron-Emission Tomography; Radiopharmaceuticals; *Sarcoma, Ewing/diagnostic imaging/pathology; Sensitivity and Specificity; Tomography, X-Ray Computed; 18f-fdg pet; Ewing sarcoma; Pet/ct; diagnostic accuracy; meta-analysis; metastasis; recurrence
Department(s): Radiation Oncology
PubMed ID: 34709700
Publisher's Version: https://doi.org/10.1002/pbc.29415
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-04-04 12:33:46

Last Modified: 2025-04-04 12:35:17